职位描述
职责描述:
Position Summary
We are seeking a highly motivated and experienced Researcher to join our high-throughput screening (HTS) team. The successful candidate will be responsible for performing qualitative and quantitative analysis of complex samples using high-resolution LC-MS platforms to support our screening pipeline. The ideal candidate is passionate about mass spectrometry, possesses strong hands-on technical skills, and maintains a rigorous, detail-oriented approach to science.
Key Responsibilities
• Operate, maintain, and troubleshoot liquid chromatography-high-resolution mass spectrometry (LC-HRMS) systems independently.
• Develop, optimize, and validate robust LC-MS methods for various analytical challenges.
• Perform characterization, identification, and quantification of small molecules or proteins using HRMS (QTOF or Orbitrap).
• Accurately and promptly document all experimental procedures, data, and results in an Electronic Laboratory Notebook (ELN).
• Process, interpret, and analyze complex HRMS data using relevant software; prepare clear and concise analytical reports.
• Collaborate effectively with cross-functional team members to provide critical mass spectrometry data and insights for project advancement.
• Adhere strictly to all laboratory safety protocols and standard operating procedures (SOPs).
任职要求:
Essential Requirements:
• Education: Master's degree with 5 years of relevant work experience; or Ph.D. degree. Field of Study: Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
• Experience: A minimum of 5 years of hands-on experience operating and maintaining liquid chromatography-mass spectrometry (LC-MS) systems.
• Core Technical Skills:
o Substantial practical experience with high-resolution mass spectrometry; proficiency in at least one platform, either QTOF or Orbitrap.
o Strong expertise in LC-MS method development, optimization, and troubleshooting.
o Proven ability to process and interpret HRMS data using software such as MassHunter, Qual Browser, or similar.
• Documentation: Meticulous record-keeping abilities with demonstrated experience using an Electronic Laboratory Notebook (ELN).
• Competencies: Excellent problem-solving, analytical, and critical thinking skills.
• Attitude: Highly responsible, detail-oriented, with strong teamwork and communication abilities.
Preferred Qualifications:
• Research experience in HTS is highly desirable.
• Research experience in ASMS is highly desirable.
• Hands-on experience for Rapid-fire MS is a plus.
• Coding skill in Python or R is a plus.
• Strong written and verbal communication skills in English, with a record of scientific publications or technical reports being a plus.